Complement and microglia mediate early synapse loss in Alzheimer mouse models. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Hepatocytes: a key cell type for innate immunity. Preclinical assessment of young blood plasma for Alzheimer disease. Physiological blood-brain transport is impaired with age by a shift in transcytosis. Functional roles of the interaction of APP and lipoprotein receptors. Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle.
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Contact activation-induced complex formation between complement factor H and coagulation factor XIIa. Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Changes in mouse uterine transcriptome in estrus and proestrus. S., Suvorov, A., Connerney, J., Lodato, N. Sex differences in human skeletal muscle fatigue. Complement and coagulation: strangers or partners in crime? Trends Immunol. Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration. Brain endothelial cells are exquisite sensors of age-related circulatory cues. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. Exercise-induced activated platelets increase adult hippocampal precursor proliferation and promote neuronal differentiation. VEGF is necessary for exercise-induced adult hippocampal neurogenesis. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. Exercise effects on brain and behavior in healthy mice, Alzheimer’s disease and Parkinson’s disease model-a systematic review and meta-analysis. Midlife cardiovascular fitness and dementia: a 44-year longitudinal population study in women. Improved cognitive performance following aerobic exercise training in people with traumatic brain injury. Running enhances neurogenesis, learning, and long-term potentiation in mice. Voluntary exercise promotes glymphatic clearance of amyloid beta and reduces the activation of astrocytes and microglia in aged mice. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease.
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Physical activity and cognitive vitality. These findings demonstrate the existence of anti-inflammatory exercise factors that are transferrable, target the cerebrovasculature and benefit the brain, and are present in humans who engage in exercise. Patients with cognitive impairment who participated in structured exercise for 6 months had higher plasma levels of CLU. Intravenously injected CLU binds to brain endothelial cells and reduces neuroinflammatory gene expression in a mouse model of acute brain inflammation and a mouse model of Alzheimer’s disease. Plasma proteomic analysis revealed a concerted increase in complement cascade inhibitors including clusterin (CLU).
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Here we show that ‘runner plasma’, collected from voluntarily running mice and infused into sedentary mice, reduces baseline neuroinflammatory gene expression and experimentally induced brain inflammation. The cognitive benefits of physical exercise are tied to an increased plasticity and reduced inflammation within the hippocampus 2, 3, 4, yet little is known about the factors and mechanisms that mediate these effects. Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration 1. Nature volume 600, pages 494–499 ( 2021) Cite this article Exercise plasma boosts memory and dampens brain inflammation via clusterin